CEFUROXIME 500MGCEFUROXIME 500 MG: – Cefuroxime Tablets is an antibiotic that is active against a wide range of gram-positive and gram-negative bacteria. It is a cephalosporin antibiotic. It acts by inhibiting bacterial cell wall growth.PHARMACODYNAMICS: – Cefuroxime Tablets is a second-generation cephalosporin, this works as penicillin. It interrupts the synthesis of the bacterial cell walls by interfering with the formation of major components essential for the formation of cell walls i.e. peptidoglycan. Like penicillins, Cefuroxime Tablets binds to penicillin-binding proteins in the bacterial cell wall which affects the synthesis of the bacterial cell wall. Ultimately, Cell lysis is initiated with autolytic enzymes in the cell wall such as autolysins.PHARMACOKINETICS:-ABSORPTION: – The absorption takes place from the GIT. It is observed that absorption is greater in the presence of food.PROTEIN BINDING: – About half of the drug concentration binds to serum protein.METABOLISM: – The metabolized components are acetaldehyde and acetic acid.HALF-LIFE: – On intramuscular or intravenous injection 80 minutes of Half-Life is observed.INDICATIONS: –Cefuroxime Tablets treats different types of bacterial infections like: –Urinary Tract InfectionsTonsillitisGonorrheaEar infectionsBronchitis




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