8 Products

- BAREC (RABEPRAZOLE 20 MG) is used to treat certain stomach and esophagus problems (such as acid reflux

- ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn

- difficulty swallowing

- and persistent cough PHARMACOLOGY PHARMACODYNAMICS: Mechanism of Action: – Rabeprazole sodium belongs to the class of anti-secretory compounds

- PANTOPRAZOLE 40 MG Packing: - 10X10 M.R.P: -550   PANTOPRAZOLE 40 MG is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. It can be used as a maintenance therapy for long term use after initial response is obtained. Pharmacokinetics Pantoprazole inhibits H+/K+ ATPase pump function thereby reducing gastric acid secretion. It also has a role in the eradication of H. pylori. Absorption : -Well absorbed; peak plasma concentrations: Approx 2-2.5 hr after oral dose. Oral bioavailability: Approx 77% with enteric-coated formulation (does not vary after single or multiple doses). Distribution Protein-binding: 98%; volume of distribution: 11-24 L. Metabolism Hepatic; mainly by cytochrome CYP2C19 and slightly by CYP2D6 and CYP2C0. Excretion Via urine (approx 80%) and bile (approx 20%). Elimination half life: approx 1 hour (prolonged in hepatic impairment; in patients with cirrhosis the elimination half life may be 3-10 hours).

- PANTOPRAZOLE 40 MG

- DOMPERIDONE 10 MG Packing: -10X10 M.R.P: - 650   PANTOPRAZOLE 40 MG & DOMPERIDONE 10 MG: - Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease whereas Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis

- causes prolactin release

- and is used as antiemetic. Pantoprazole acts by selectively inhibiting the H+/K+-ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors. Pharmacology: Pantoprazole: Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production. Pantoprazole is unstable in acid and is administered orally in the form of an enteric-coated tablet Pantoprazole is completely and rapidly absorbed after oral administration. The absolute bioavailability from the tablet was found to be about 77 %. Pantoprazole is extensively metabolized in the liver through the cytochrome P450 (CYP) system. Renal elimination represents the major route of excretion (about 80%) for the metabolites of Pantoprazole; the rest is excreted with the faeces. Domperidone: Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of Domperidone are related to its peripheral dopamine receptor blocking properties.. In fasting subjects

- RABEPRAZOLE 20mg

- LEVOSULPRIDE 75mg. PHARMACOLOGY PHARMACODYNAMICS 1.) Rabeprazole: – Rabeprazole belongs to a class of anti secretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties

- but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell

- rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells

- OMEPRAZOLE 20mg

- DOMPERIDONE 10mg PHARMACOLOGY 1.OMEPRAZOLE a.)Pharmacodynamics: – After oral administration

- the onset of the anti-secretory effect of omeprazole occurs within one hour and maximum effect occurring within two hours. At 24 hours

- inhibition of secretion is approximately 50% of maximum and duration of inhibition lasts up to 72 hours. Although omeprazole has a very short plasma half-life

- PANTOPRAZOLE 40 MG

- DOMPERIDONE 30 MG SR CAPSULE Packing: -10X10 M.R.P: - 890     Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease whereas Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis

- causes prolactin release

- and is used as antiemetic and tool in the study of dopaminergic mechanisms. Pantoprazole acts by selectively inhibiting the H+/K+-ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors. Pharmacology a.) Pharmacokinetics: - 1. Pantoprazole: Absorption: - Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production. Pantoprazole is unstable in acid and is administered orally in the form of an enteric-coated tablet Pantoprazole is completely and rapidly absorbed after oral administration. Bioavailability: - The absolute bioavailability from the tablet was found to be about 77 %. Metabolism: - Pantoprazole is extensively metabolized in the liver through the cytochrome P450 (CYP) system. Elimination: - Renal elimination represents the major route of excretion (about 80%) for the metabolites of Pantoprazole; the rest is excreted with the feces. 2. Domperidone: Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of Domperidone are related to its peripheral dopamine receptor blocking properties. Absorption: - Domperidone is rapidly absorbed after oral administration. Protein Binding: - Domperidone is 91-93% bound to plasma proteins. Metabolism: -Domperidone undergoes rapid and extensive hepatic metabolism Elimination: - Urinary and faecal excretions amount to 31 and 66% of the oral dose respectively. Indications: Antacids Antireflux Agents & Antiulcerants / GIT Regulators

- RABEPRAZOLE 20mg

- DOMPERIDONE 30mg RABEPRAZOLE is widely utilized to prevent and heal gastrointestinal (stomach and guts) problems

- which is caused due to overmuch stomach acid. Rabebrazole is a proton pump inhibitor (PPI)

- sometimes identified as an ulcer healing drug. This is also very beneficial for inhibiting secretion and gastric from the stomach as well as to treat various acid related gastrointestinal conditions. It heals stomach and intestinal ulcers and manages gastro-esophageal reflux disease (GORD a condition in which acid rises up from the stomach into the esophagus with symptoms of heartburn

- RABEPRAZOLE SODIUM Injection RABEPRAZOLE Rabeprazole is used to treat certain stomach and esophagus problems (such as acid reflux

- ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn

- difficulty swallowing

- and persistent cough. PHARMACOLOGY PHARMACODYNAMICS: Mechanism of Action: – Rabeprazole sodium belongs to the class of anti-secretory compounds