5 Products

- PIROXICAM

- COMPOSITION: – TRYPSIN

- CHYMOTRYPSIN (50

- 000 I.U.)

- DICLOFENAC 50MG

- ETORICOXIB 90 MG   Docru contains the composition of Etoricoxib Tablets which is an anti-inflammatory medicine used to relieve pain

- swelling

- and inflammation in the body. It belongs to the class of drug which is a non-steroidal anti-inflammatory drug (NSAID) that treats the conditions due to arthritis. Etoricoxib Tablets work by decreasing the built-up of prostaglandins

- a chemical reason behind the pain

- (ACECLOFENAC 100 MG + THIOCHOLCHISIDE 4 MG)   PHARMACOLOGY PHARMACODYNAMICS OF THIOCOLCHICOSIDE Mechanism of Action: – Thiocolchicide is a GABA-A receptor antagonist

- which binds to GABA-A and strychnine-sensitive glycine receptors. This results from the reduction of spasticity. It also has myorelaxant effects at the supraspinal level

- via complex regulatory mechanisms. PHARMACODYNAMICS OF ACECLOFENAC Mechanism of Action: – It inhibits cyclo-oxygenase (COX) activity and suppresses the PGE2 production by inflammatory cells

- by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action). It blocks degeneration and stimulates the synthesis of the extracellular matrix of cartilages by inhibiting the action of different cytokines. Drugs and their metabolites inhibit IL-6 production by human chondrocytes. This leads to inhibition of increase of inflammatory cells in synovial tissue

- (DICLOFENAC SODIUM INJ(1ML)   Pharmacology Pharmacokinetics Diclofenac Sodium • Absorption: – Diclofenac is NSAID with anti-inflammatory

- analgesic and antipyretic properties. It is rapidly and almost completely absorbed when administered as an oral dose. Food does not have a significant effect on the extent of oral absorption. • Protein Binding: -At therapeutic concentrations

- it is more than 99% bound to plasma proteins. Metabolism: -Diclofenac and/or its metabolites are rapidly and preferentially taken up and retained in inflamed tissues. It penetrates synovial fluid where concentrations may persist even when plasma concentrations fall. • Half-Life: – The terminal half-life is about 1 to 2 hours. Diclofenac acts by inhibiting cyclooxygenase

- thus prevents the formation of prostaglandins