2 Products
in Anti Ulcer, Anti Gas, Digestive & Anti Emetics
EMDAR Injection
- ONDENSETRON 4mgPHARMACOLOGY 1. Pharmacokinetics: - Absorption: Owing to hepatic first-pass metabolism
- its bioavailability is only about 60%. Distribution: Plasma protein binding of ondensetron as measured in vitro was 70% to 76%
- over the Pharmacologic concentration range of 10 to 500 ng/mL. Circulating drug also distributes into erythrocytes. Metabolism: Ondensetron is extensively metabolized in humans
- with approximately 5% of a radiolabeled dose recovered as the parent compound from the urine. The primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation. Elimination: In adult cancer patients
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