NIZBRO-200 SR Tablets

NIZBRO-200 SR Tablets

Description

ACEBROPHYLLINE 200 MG Packing: -10X10 M.R.P: - 1420ACEBROPHYLLINE HAS 3 ACTIONS NAMELY BRONCHODILATION, MUCOREGULATION & ANTI-INFLAMMATORY ACTION. PHARMACOLOGY A.) PHARMACODYNAMICS: Acebrophylline inhibits intracellular phosphodiesterase associated significantly reduce the airway inflammation and obstruction in chronic stages. Acebrophylline increases the synthesis and release of alveolar surfactant, resulting in triple action: mucoregulation, stimulation of bronchoalveolar clearance, and anti-inflammatory-antireactive effect. In patients with chronic obstructive bronchitis, given the drug for 10-20 days, there was a good reduction in expectorate Viscosity.with cAMP levels and facilitates bronchial muscles relaxation. Acebrophylline selectively inhibits phosphatidylcholine and phospholipase A, TNF-alpha and leukotrienes. Inhibition of such pro-inflammatory mediators can. B.) PHARMACOKINETICS: • Absorption: – 200mg oral acebrophylline, the two components of the molecule ambroxol and theophylline-7-acetic acid are released in the stomach and absorbed in the intestine, reaching optimal concentrations of ambroxol within 2 hrs and of theophylline-7-acetic acid after 1 hr. • Half-Life: – The plasma half life varies from 4 to 9 hrs after oral administration. • Metabolism: – The drug is metabolized in the liver and eliminated renally. Indications Treatment of adult patients with COPD and bronchial asthma.

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Pharmaceutical Tablets

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10*10

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