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BAREC-AC CAPSULE
Description
ENTERIC COATED RABEPRAZOLE SODIUM 200 MG, ACECLOFENAC SUSTAINED RELEASE
Rabeprazole is widely utilized to prevent and heal gastrointestinal (stomach and guts) problems, which are caused due to overmuch stomach acid. Rabeprazole is a proton pump inhibitor (PPI), sometimes identified as an ulcer healing drug. This is also very beneficial for inhibiting secretion and gastric from the stomach as well as to treat various acid-related gastrointestinal conditions. It heals stomach and intestinal ulcers and manages gastro-esophageal reflux disease (GORD a condition in which acid rises from the stomach into the esophagus with symptoms of heartburn, acid regurgitation, and pain on swallowing).
RABEPRAZOLE
Rabeprazole sodium is a proton pump inhibitor. It is a prodrug. After administration, it diffuses into the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Rabeprazole is converted to sulfenamide. This sulfenamide covalently interacts with the sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ions. Rabeprazole sodium irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Rabeprazole produces the fastest acid suppression and helps in mucin synthesis.
PHARMACOKINETICS:
Rabeprazole
• Absorption: Rabeprazole sodium is well absorbed after oral administration and its bioavailability is about 50% since it undergoes the first-pass metabolism.
• Distribution: It is widely distributed in the body in protein-bound form.
• Metabolism: Rabeprazole sodium is extensively metabolized in the liver.
• Excretion: It is excreted mainly in the urine and a small amount in feces.
Domperidone
• Absorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first-pass metabolism oral bioavailability is only 15 %.
• Distribution: It is widely distributed in the body in protein-bound form.
• Metabolism: Domperidone undergoes metabolism in the liver.
• Excretion: It is excreted mainly in the feces and also in the urine.
INDICATION
Gerd, Heart Burn & Hyperacidity. Reflux Oesophagitis. Regurgitation & Flatulence, Gastric & Peptic Ulcer.
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