FEXMARE Tablets

FEXOFENADINE120mg, MONTELUKAST10mg

 

Metabolism May Be Increased With Rifampicin, Phenobarbital, Phenytoin. Peripheral Oedema May Occur With Prednisone.

 

Mechanism of Action of Montelukast 10mg + Fexofenadine 120mg: Montelukast Is A Selective Leukotriene Receptor Antagonist That Blocks The Effects Of Cysteinyl Leukotrienes In The Airways.

• Absorption: Rapidly Absorbed From The GI Tract (Oral).
• Peak Plasma Concentrations In 2-4 Hr. Mean Oral Bioavailability: 64%. Distribution: Protein-Binding: >99%. Metabolism: Extensively Hepatic By CYP3A4, CYP2A6 And CYP2C9 Isoenzymes.
• Excretion: Principally Via Faeces; Elimination Half-Life Prolonged In Mild To Moderate Hepatic Impairment.